Resistance in mBC

Treatment resistance to current therapies remains an issue for patients with metastatic breast cancer (mBC)3-5

When the interval between treatment and recurrence is brief, treatment resistance is the likely cause3

  • Due to the use of anthracyclines and taxanes in the adjuvant setting, the emergence of resistance may limit their use in the metastatic setting3,5,6

Some common causes of resistance to taxanes and other chemotherapies5

Defined resistance criteria used in IXEMPRA® (ixabepilone) registrational studies1

HER2, human epidermal growth factor receptor 2.
* For anthracyclines, patients who received a minimum cumulative dose of 240 mg/m2 of doxorubicin or 360 mg/m2 of epirubicin were also eligible.

References: 1. IXEMPRA (ixabepilone) Prescribing Information; January 2016. 2. Perez EA. Microtubule inhibitors: differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance. Mol Cancer Ther. 2009;8(8):2086-2095. 3. Yardley DA. Drug resistance and the role of combination chemotherapy in improving patient outcomes. Int J Breast Cancer. 2013;2013:137414. doi:10.1155/2013/137414. 4. Longley DB, Johnston PG. Molecular mechanisms of drug resistance. J Pathol. 2005;205(2):275-292. 5. Coley HM. Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer. Cancer Treat Rev. 2008;34(4):378-390. doi:10.1016/j.ctrv.2008.01.007.

Indications and Important Safety Informationexpand

Important Safety Information

IXEMPRA is contraindicated in patients:


Toxicity in patients with hepatic impairment

Peripheral neuropathy


Hypersensitivity reactions

Cardiac adverse reactions


Alcohol Content


Adverse reactions


Combination with capecitabine

Cremophor is a registered trademark of BASF AG.
AST = aspartate aminotransferase; ALT = alanine aminotransferase; ULN = upper limit of normal; CTC = common terminology criteria.


IXEMPRA® (ixabepilone) is indicated for treatment in combination with capecitabine for patients with metastatic or locally advanced breast cancer resistant to treatment with an anthracycline and a taxane, or whose cancer is taxane resistant and for whom further anthracycline therapy is contraindicated.

IXEMPRA is indicated for treatment as a single agent for patients with metastatic or locally advanced breast cancer after failure of an anthracyclines, taxanes, and capecitabine.

Please see US Full Prescribing Information, including boxed WARNING regarding hepatic impairment.


Medical information

For product information or to report an adverse reaction, please call 1-844-586-8953 or e mail

This site is intended for US healthcare professionals.

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