• About IXEMPRA
• How IXEMPRA May Help
  • IXEMPRA Used Alone
  • IXEMPRA Used
    With Xeloda
• How IXEMPRA Is
  Thought to Work
• How IXEMPRA Is Given
• Possible Side Effects
  of IXEMPRA
  • Serious Side Effects
    of IXEMPRA
  • Common Side Effects
    of IXEMPRA
• Tips for Coping
  With Certain Side Effects
• IXEMPRA Reimbursement

Tingling, numbness, or burning in the hands or feet, or extreme
sensitivity to touch (peripheral neuropathy)

Peripheral neuropathy (PN) is an unpleasant feeling in the hands and feet that is caused by nerve damage. This can lead to problems, such as weakness, balance problems, and trouble walking. Your dose of IXEMPRA may need to be lowered or stopped until these symptoms get better. Or you may need to stop taking IXEMPRA permanently. Be sure to follow your healthcare provider’s advice on ways to manage PN.

In one clinical trial, 67% of women who received IXEMPRA and Xeloda had PN

In another clinical trial, 63% of women who received IXEMPRA alone had PN

Low white blood cell count (neutropenia)

Having a low white blood cell count means your body cannot fight infections very well and you have a greater chance of getting an infection. Signs of infection can include fever (temperature over 100.5°F), chills, cough, and/or burning or pain when urinating. If you get a fever or infection when your white blood cells are very low, you can become seriously ill and die. You may need treatment in the hospital with antibiotic medicines. Your healthcare provider will monitor your white blood cell count often with blood tests. Tell your healthcare provider right away or go to the nearest hospital emergency room if you have signs of infection.

In one clinical trial, 36% of women who received IXEMPRA and Xeloda and 2% of women who received Xeloda alone had severe neutropenia

In another clinical trial, 23% of women who received IXEMPRA alone had severe neutropenia

Severe allergic reaction

Some women who receive IXEMPRA have a severe allergic reaction to it. In rare cases, these allergic reactions may cause death. It may help you to know:

There are medicines that may help lower your chances of having an allergic reaction. You will receive these medicines an hour before each treatment with IXEMPRA

Allergic reactions usually happen while people are receiving IXEMPRA. Your doctor or nurse will watch you closely for signs of an allergic reaction

But you should also be aware of the signs of an allergic reaction. Watch for:

Itching, hives, or rash

Flushed (red) face

Sudden swelling of the face, throat, or tongue

A tight feeling in the chest or trouble breathing

Feeling dizzy or feeling like you are going to faint

Feeling a strong, rapid heartbeat (palpitations)

Tell your healthcare provider right away if you have symptoms of an allergic reaction during treatment with IXEMPRA. Call your healthcare provider if an allergic reaction starts after your treatment is finished and you are at home.

Harm to an unborn child

You should not receive IXEMPRA during pregnancy because it may cause harm to an unborn child. Talk with your healthcare provider about how to prevent pregnancy during treatment with IXEMPRA. Tell your healthcare provider right away if you become pregnant or think you are pregnant while receiving IXEMPRA.

Heart problems

Heart problems may happen when the heart does not pump blood properly. This may mean that less blood flows to the heart. This can cause chest pain, trouble breathing, palpitations (being able to feel your heart beating), and unusual weight gain. In clinical trials, heart problems were reported by:

2% of women who received IXEMPRA and Xeloda

Less than 1% of women who received Xeloda alone

Please see the complete Important Safety Information, including boxed WARNING regarding liver disease.